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Article

GluRδ2 assembles four neurexins into trans-synaptic triad to trigger synapse formation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Mar 2012

Lee Sung-Jin, Uemura Takeshi, Yoshida Tomoyuki, Mishina Masayoshi

Abstract excerpt

Elucidation of molecular mechanisms of synapse formation is a prerequisite for the understanding of neural wiring, higher brain functions, and mental disorders. The trans-synaptic interaction of postsynaptic glutamate receptor δ2 (GluRδ2) and presynaptic neurexins (NRXNs) through cerebellin precursor protein 1 (Cbln1) mediates synapse formation in vivo in the cerebellum. Here, we asked how the trans-synaptic...

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Identifiers

PMID: 22457515
DOI: 10.1523/JNEUROSCI.5584-11.2012
PMCID: PMC6622077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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