Article
Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.4.
Biochemical and biophysical research communications - 20 Mar 2009
Ishihara Keiko, Yamamoto Tomomi, Kubo Yoshihiro
Abstract excerpt
Heteromultimerization of different pore-forming subunits is known to contribute to the diversity of inward rectifier K(+) channels. We examined if the subunits belonging to different subfamilies Kir2 and Kir3 can co-assemble to form heteromultimers in heterologous expression systems. We observed co-immunoprecipitation of Kir2.1 and Kir3.1 as well as Kir2.1 and Kir3.4 in HEK293T cells. Furthermore, analyses of...
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