Article

Kirrel3-mediated synapse formation is attenuated by disease-associated missense variants

2019-12-30

Abstract excerpt

<h4>ABSTRACT</h4> Missense variants in Kirrel3 are repeatedly identified as risk factors for autism spectrum disorder and intellectual disability but it has not been reported if or how these variants disrupt Kirrel3 function. Previously, we studied Kirrel3 loss-of-function using knockout mice and showed that Kirrel3 is a synaptic adhesion molecule necessary to form one specific type of hippocampal synapse in vivo...

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Literature Corpus work: b0c68d29-1b0b-5410-93c1-24ded4632359
DOI: 10.1101/2019.12.30.891085

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