Article
A contextual model for axonal sorting into glomeruli in the mouse olfactory system.
Cell - 11 Jun 2004
Feinstein Paul, Mombaerts Peter
Abstract excerpt
No models fully account for how odorant receptors (ORs) function in the guidance of axons of olfactory sensory neurons (OSNs) to glomeruli in the olfactory bulb. Here, we use gene targeting in mice to demonstrate that the OR amino acid sequence imparts OSN axons with an identity that allows them to coalesce into glomeruli. Replacements between the coding regions of the M71 and M72 OR genes reroute axons to their...
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