A contextual model for axonal sorting into glomeruli in the mouse olfactory system.

doi:10.1016/j.cell.2004.05.011

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Article

A contextual model for axonal sorting into glomeruli in the mouse olfactory system.

Cell - 11 Jun 2004

Feinstein Paul, Mombaerts Peter

Abstract excerpt

No models fully account for how odorant receptors (ORs) function in the guidance of axons of olfactory sensory neurons (OSNs) to glomeruli in the olfactory bulb. Here, we use gene targeting in mice to demonstrate that the OR amino acid sequence imparts OSN axons with an identity that allows them to coalesce into glomeruli. Replacements between the coding regions of the M71 and M72 OR genes reroute axons to their...

Topics

Amino Acid Sequence
Animals
Cell Communication
Cell Differentiation
Cell Membrane
Gene Expression Regulation, Developmental
Gene Targeting
Growth Cones
Mice
Mice, Transgenic
Models, Biological
Olfactory Bulb
Olfactory Receptor Neurons
Open Reading Frames
Phenotype
Polymorphism, Genetic
Protein Structure, Tertiary
Receptors, Odorant

Source

Open in PubMed

Identifiers

PMID: 15186781
DOI: 10.1016/j.cell.2004.05.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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