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Article

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes

19 Jan 2016

Abstract excerpt

The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive membrane protein signalling complexes. Whereas podocin resides at a specialized cell junction at the podocyte slit diaphragm, MEC-2 is found in neurons required for...

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PMID: 26792178
DOI: 10.1093/hmg/ddw016

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