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Article

Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism.

Nature communications - 1 May 2020

Li Jingxian, Xie Yuan, Cornelius Shaleeka, Jiang Xian, Sando Richard, Kordon Szymon P, Pan Man, Leon Katherine, Südhof Thomas C, Zhao Minglei, Araç Demet

Abstract excerpt

The trans-synaptic interaction of the cell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs/ADGRLs) promotes excitatory synapse formation when LPHNs simultaneously interact with FLRTs. Insertion of a short alternatively-spliced region within TENs abolishes the TEN-LPHN interaction and switches TEN function to specify inhibitory synapses. How alternative-splicing regulates TEN-LPHN interaction remains...

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Identifiers

PMID: 32358586
DOI: 10.1038/s41467-020-16029-7
PMCID: PMC7195488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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