Article
HIV-1 Genetic Diversity and Natural Polymorphisms of the Integrase Gene in Integrase Inhibitor-Naive Patients in Harare, Zimbabwe.
AIDS research and human retroviruses - 1 Dec 2021
Madyadi Amanda, Dhoro Milcah, Shamu Tinei, Washaya Tendai, Kouamou Vinie, Chimukangara Benjamin, Katzenstein David, Manasa Justen
Abstract excerpt
Previously used as part of salvage therapy, integrase strand transfer inhibitors (INSTIs) have become part of the preferred antiretroviral therapy (ART) first-line regimen in most low- to middle-income countries. With the extensive use of dolutegravir in first-line ART, drug resistance mutations to INSTIs are inevitable. Therefore, active monitoring and surveillance of INSTI drug resistance is required. The aim...
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