Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pre-treatment integrase inhibitor resistance is uncommon in antiretroviral therapy-naive individuals with HIV-1 subtype A1 and D infections in Uganda.

AIDS (London, England) - 1 Jun 2021

McCluskey Suzanne M, Kamelian Kimia, Musinguzi Nicholas, Kigozi Simone, Boum Yap, Bwana Mwebesa B, Muzoora Conrad, Brumme Zabrina L, Carrington Mary, Carlson Jonathan, Foley Brian, Hunt Peter W, Martin Jeffrey N, Bangsberg David R, Harrigan P Richard, Siedner Mark J, Haberer Jessica E, Lee Guinevere Q

Abstract excerpt

OBJECTIVE: Dolutegravir (DTG) is now a preferred component of first-line antiretroviral therapy (ART). However, prevalence data on natural resistance to integrase inhibitors [integrase strand transfer inhibitors (INSTIs)] in circulating non-subtype B HIV-1 in sub-Saharan Africa is scarce. Our objective is to report prevalence of pre-treatment integrase polymorphisms associated with resistance to INSTIs in an...

Topics

Join the communities discussing this publication.

Africa South of the Sahara
Drug Resistance, Viral
HIV-1
HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV Integrase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 33635845
DOI: 10.1097/QAD.0000000000002854
PMCID: PMC8102316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pre-treatment integrase inhibitor resistance is uncommon in antiretroviral therapy-naive individuals with HIV-1 subtype A1 and D infections in Uganda.PMID 33635845Read ↗

Accumulation of integrase strand transfer inhibitor resistance mutations confers high-level resistance to dolutegravir in non-B subtype HIV-1 strains from patients failing raltegravir in Uganda.Semantic proximity Read ↗

Limited emergence of resistance to Integrase strand transfer inhibitors (INSTIs) in HIV-experienced patients failing dolutegravir-based antiretroviral therapy: Cross-sectional analysis from a Northeast Nigerian cohortSemantic proximity Read ↗

Primary resistance to integrase strand transfer inhibitors in patients infected with diverse HIV-1 subtypes in sub-Saharan Africa.Semantic proximity Read ↗

Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study.Semantic proximity Read ↗

Comparison of HIV drug resistance profiles across HIV-1 subtypes A and D for patients receiving a tenofovir-based and zidovudine-based first line regimens in Uganda.Semantic proximity Read ↗

From antiretroviral therapy access to provision of third line regimens: evidence of HIV Drug resistance mutations to first and second line regimens among Ugandan adults.Semantic proximity Read ↗

Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first- and second-line ART in Tanzania.Semantic proximity Read ↗

HIV-1 Drug Resistance Among Ugandan Adults Attending an Urban Out-Patient Clinic.Semantic proximity Read ↗

Low Levels of Clinically Significant Drug Resistance Mutations to Dolutegravir Among Children Living with HIV Failing on First-Line Antiretroviral Therapy in Uganda.Semantic proximity Read ↗

Integrase strand-transfer inhibitor polymorphic and accessory resistance substitutions in patients with acute/recent HIV infectionSemantic proximity Read ↗

Emerging integrase strand transfer inhibitor drug resistance mutations among children and adults on ART in Tanzania: findings from a national representative HIV drug resistance survey.Semantic proximity Read ↗

Prevalence of integrase strand transfer inhibitor resistance mutations in antiretroviral-naive HIV-1-infected individuals in Cameroon.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.