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Prevalence of HIV-1 Natural Polymorphisms and Integrase-Resistance-Associated Mutations in African Children.

Viruses - 16 Feb 2023

Fofana Djeneba B, Diarra Houdou, Guindo Ibrahima, Savadogo Mahamadou K, d'Almeida Marceline, Diallo Fatoumata I, Baldé Aliou, Soulié Cathia, Kone Amadou, Marcelin Anne-Geneviève, Maiga Almoustapha I, Lambert-Niclot Sidonie, Maiga Mamoudou, McFall Sally, Hawkins Claudia A, Murphy Robert L, Sylla Mariam, Katlama Christine, Holl Jane L, Calvez Vincent, Morand-Joubert Laurence

Abstract excerpt

Integrase inhibitors (INIs) are a potent option for HIV treatment. Limited data exist on INI resistance in West Africa, particularly in children living with HIV/AIDS. We determined the prevalence of integrase gene polymorphisms and the frequency of naturally occurring amino acid (aa) substitutions at positions associated with INI resistance. Dried blood spot (DBS) samples were obtained from one hundred and seven...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36851760
DOI: 10.3390/v15020546
PMCID: PMC9964382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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