Article
HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon.
AIDS research and human retroviruses - 1 May 2020
Mikasi Sello Given, Gichana Josiah Otwoma, Van der Walt Cheri, Brado Dominik, Obasa Adetayo Emmanuel, Njenda Duncan, Messembe Martha, Lyonga Emilia, Assoumou Okomo, Cloete Ruben, Ikomey George Mondinde, Jacobs Graeme Brendon
Abstract excerpt
The World Health Organization (WHO) has put forth recommendations for the use of integrase (IN) strand transfer inhibitors (INSTIs) to be part of the first-line combination antiretroviral therapy regimen to treat HIV infections. The knowledge of pretreatment drug resistance against INSTIs is still scarce in resource-limited settings (RLS). We characterized the integrase gene to identify resistance-associated...
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