Baseline integrase drug resistance mutations and conserved regions across HIV-1 clades in Cameroon: implications for transition to dolutegravir in resource-limited settings.

doi:10.1093/jac/dkab004

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Article

Baseline integrase drug resistance mutations and conserved regions across HIV-1 clades in Cameroon: implications for transition to dolutegravir in resource-limited settings.

The Journal of antimicrobial chemotherapy - 13 Apr 2021

Semengue Ezechiel Ngoufack Jagni, Armenia Daniele, Inzaule Seth, Santoro Maria Mercedes, Dambaya Béatrice, Takou Désiré, Teto Georges, Nka Alex Durand, Yagai Bouba, Fabeni Lavinia, Chenwi Collins, Angong Beloumou Grâce, Djupsa Ndjeyep Sandrine Claire, Colizzi Vittorio, Perno Carlo-Federico, Ceccherini-Silberstein Francesca, Fokam Joseph

Abstract excerpt

BACKGROUND: Transition to dolutegravir-based regimens in resource-limited settings (RLS) requires prior understanding of HIV-1 integrase variants and conserved regions. Therefore, we evaluated integrase drug resistance mutations (DRMs) and conserved regions amongst integrase strand transfer inhibitor (INSTI)-naive patients harbouring diverse HIV-1 clades in Cameroon. METHODS: A cross-sectional study was conducted...

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PMID: 33501504
DOI: 10.1093/jac/dkab004

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