Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice.

Nature communications - 27 Oct 2021

Pessoa Rodrigues Cecilia, Chatterjee Aindrila, Wiese Meike, Stehle Thomas, Szymanski Witold, Shvedunova Maria, Akhtar Asifa

Abstract excerpt

Noncommunicable diseases (NCDs) account for over 70% of deaths world-wide. Previous work has linked NCDs such as type 2 diabetes (T2D) to disruption of chromatin regulators. However, the exact molecular origins of these chronic conditions remain elusive. Here, we identify the H4 lysine 16 acetyltransferase MOF as a critical regulator of central carbon metabolism. High-throughput metabolomics unveil a systemic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Adipocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carbon

Share to Diet, High-Fat

Share to Glucose Transporter Type 4

Share to Haploinsufficiency

Share to Histone Acetyltransferases

Share to PPAR gamma

Source

Open in PubMed Open full text

Identifiers

PMID: 34707105
DOI: 10.1038/s41467-021-26277-w
PMCID: PMC8551339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice.PMID 34707105Read ↗

Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cyclingSemantic proximity Read ↗

The mitochondrial thiolase ACAT1 regulates monocyte/macrophage type I interferon <i>via</i> epigenetic controlSemantic proximity Read ↗

HDAC11 Deficiency Prevents High-Fat Diet-Induced Obesity and Metabolic SyndromeSemantic proximity Read ↗

Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet-induced obesitySemantic proximity Read ↗

The polyol pathway is an evolutionarily conserved system for sensing glucose uptakeSemantic proximity Read ↗

O-GlcNAcylation regulates PPAR-driven metabolic programming in intestinal stem cellsSemantic proximity Read ↗

<i>In Vivo</i> Quantification of Histone Acetylation Turnover and Acetyl-CoA Sources Using ²H₂O Metabolic Labeling and High-Resolution Mass SpectrometrySemantic proximity Read ↗

AZIN2-dependent polyamine metabolism determines adipocyte progenitor fate and protects against obesity and dysmetabolismSemantic proximity Read ↗

Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesisSemantic proximity Read ↗

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolismSemantic proximity Read ↗

Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.Semantic proximity Read ↗

HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.