Article

Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet-induced obesity

2025-12-09

Abstract excerpt

<h4>Objectives</h4> Histone deacetylase 7 (HDAC7), a classical HDAC family member, promotes LPS-inducible glycolysis and inflammatory mediator production in macrophages, innate immune cells that contribute to pathology in metabolic diseases. Here, we investigated myeloid HDAC7 functions in obesity-driven metabolic disease. <h4>Methods</h4> We used gain- and loss-of-function genetic approaches in mice to investig...

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Literature Corpus work: 20f2c422-ae00-5ed5-9c28-d9ff9e902859
DOI: 10.64898/2025.12.04.691405

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