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Article

Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis

13 Jan 2025

Abstract excerpt

Obesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples. MCJKO mice, even...

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PMID: 39805849
DOI: 10.1038/s41467-024-54353-4

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