Article

AZIN2-dependent polyamine metabolism determines adipocyte progenitor fate and protects against obesity and dysmetabolism

2024-11-20

Abstract excerpt

<h4>Summary</h4> Adipose tissue homeostasis plays a critical role in metabolic disease but the metabolic circuitry regulating adipose tissue dynamics remains unclear. In this study, polyamine metabolism emerges as an important regulator of adipose tissue pathophysiology. We identify AZIN2 (Antizyme inhibitor 2), a protein promoting polyamine synthesis and acetylation, as a major regulator of total acetyl-CoA in a...

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Identifiers and source

Literature Corpus work: 7ea68082-ddbd-5256-825f-0826fd2e119a
DOI: 10.1101/2024.11.19.621837

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