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Article

Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.

Molecular metabolism - 1 Dec 2020

Mittenbühler Melanie J, Saedler Katarzyna, Nolte Hendrik, Kern Lara, Zhou Jun, Qian Shu-Bing, Meder Lydia, Ullrich Roland T, Brüning Jens C, Wunderlich F Thomas

Abstract excerpt

OBJECTIVE: Single-nucleotide polymorphisms in the FTO gene encoding an m6Am and an m6A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of m6A modifications and its machinery, including FTO, to the development of several forms of cancers. However, the functional role of hepatic FTO in metabolism and the development and progression of hepatocellular carcinoma (HCC), a...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32956847
DOI: 10.1016/j.molmet.2020.101085
PMCID: PMC7560164

Genes

FTO
CUL4A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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