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Article

A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif.

The Journal of biological chemistry - 24 Dec 2010

Albin John S, LaRue Rebecca S, Weaver Jessalyn A, Brown William L, Shindo Keisuke, Harjes Elena, Matsuo Hiroshi, Harris Reuben S

Abstract excerpt

Human APOBEC3F (huA3F) potently restricts the infectivity of HIV-1 in the absence of the viral accessory protein virion infectivity factor (Vif). Vif functions to preserve viral infectivity by triggering the degradation of huA3F but not rhesus macaque A3F (rhA3F). Here, we use a combination of deletions, chimeras, and systematic mutagenesis between huA3F and rhA3F to identify Glu(324) as a critical determinant of...

Topics

APOBEC Deaminases
Amino Acid Substitution
Animals
Cell Line
Cytidine Deaminase
Cytosine Deaminase
Genetic Predisposition to Disease
HIV Infections
HIV-1
Humans
Macaca mulatta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Protein Structure, Secondary

Protein Structure, Tertiary

Simian Immunodeficiency Virus

vif Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 20971849
DOI: 10.1074/jbc.M110.173161
PMCID: PMC3003379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif.PMID 20971849Read ↗

Identification of specific determinants of human APOBEC3F, APOBEC3C, and APOBEC3DE and African green monkey APOBEC3F that interact with HIV-1 Vif.Semantic proximity Read ↗

HIV-1 Vif gained breadth in APOBEC3G specificity after cross-species transmission of its precursorsSemantic proximity Read ↗

HIV-1 Vif Gained Breadth in APOBEC3G Specificity after Cross-Species Transmission of Its Precursors.Semantic proximity Read ↗

The Structural Interface between HIV-1 Vif and Human APOBEC3HSemantic proximity Read ↗

A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action.Semantic proximity Read ↗

Leveraging APOBEC3 Proteins to Alter the HIV Mutation Rate and Combat AIDSSemantic proximity Read ↗

A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.Semantic proximity Read ↗

Identification of Two Distinct Human Immunodeficiency Virus Type 1 Vif Determinants Critical for Interactions with Human APOBEC3G and APOBEC3FSemantic proximity Read ↗

Mutational Alteration of Human Immunodeficiency Virus Type 1 Vif Allows for Functional Interaction with Nonhuman Primate APOBEC3GSemantic proximity Read ↗

The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational ApproachesSemantic proximity Read ↗

Natural Variation in Vif: Differential Impact on APOBEC3G/3F and a Potential Role in HIV-1 DiversificationSemantic proximity Read ↗

Structural perspectives on HIV‐1 Vif and APOBEC3 restriction factor interactionsSemantic proximity Read ↗

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