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Article

Early onset of aging phenotype in vascular repair by Mas receptor deficiency.

GeroScience - 1 Feb 2022

Vasam Goutham, S Shrinidh Joshi, Miyat Su Yamin, Adam Hashim, Jarajapu Yagna P

Abstract excerpt

Aging is associated with impaired vascular repair following ischemic insult, largely due to reparative dysfunctions of progenitor cells. Activation of Mas receptor (MasR) was shown to reverse aging-associated vasoreparative dysfunction. This study tested the impact of MasR-deficiency on mobilization and vasoreparative functions with aging. Wild type (WT) or MasR-deficient mice (MasR-/- or MasR+/-) at 12-14 weeks...

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Identifiers

PMID: 34661816
DOI: 10.1007/s11357-021-00473-4
PMCID: PMC8810970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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