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Reprogramming ageing and longevity genes restores paracrine angiogenic properties of early outgrowth cells

3 Mar 2016

Abstract excerpt

AIMS: Impaired tissue vascularization is a major determinant of cardiovascular disease (CVD) in the elderly. Accumulation of reactive oxygen species (ROS) may interfere with vascular repair, but the underlying mechanisms remain unknown. Early outgrowth cells (EOCs) play an important role in endothelial repair. We investigated whether key lifespan genes involved in ROS, i.e. the mitochondrial adaptor p66(Shc) and...

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PMID: 26941203
DOI: 10.1093/eurheartj/ehw073

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