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Article

Ruxolitinib preserves endothelial function in middle-aged and old mice after ischemia/reperfusion injury.

Microvascular research - 1 Nov 2026

Saemann Lars, Soyer Hatice Seda, Pohl Sabine, Hagewiesche Saskia, Sarow Leah, Wambrauw Sara, Kuru-Schors Merve, Simm Andreas

Abstract excerpt

INTRODUCTION: Ischemia/Reperfusion (I/R) and the increasing age of patients are coexisting challenges in today's cardiovascular medicine. Vascular I/R leads to endothelial dysfunction and is partially driven by inflammation. With increasing age, a profile of biomolecules known as the senescence-associated secretory phenotype (SASP) also increases. The SASP correlates with decreased resilience and intrinsic...

Read the complete abstract on PubMed

Topics

Animals
Mice, Inbred C57BL
Vasodilation
Reperfusion Injury
Pyrimidines
Endothelium, Vascular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Pyrazoles

Age Factors

Male

Nitriles

Disease Models, Animal

Vasodilator Agents

Vasoconstriction

Time Factors

Aging

Cellular Senescence

Janus Kinase Inhibitors

Endothelial Cells

Source

Identifiers

PMID: 42628787
DOI: 10.1016/j.mvr.2026.105004

Genes

CCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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