Article
N-acetylcysteine differentially regulates the populations of bone marrow and circulating endothelial progenitor cells in mice with limb ischemia.
European journal of pharmacology - 15 Aug 2020
Cui Yuqi, Liu Lingjuan, Xiao Yuan, Li Xin, Zhang Jia, Xie Xiaoyun, Tian Jie, Sen Chandan K, He Xiaoming, Hao Hong, Liu Zhenguo
Abstract excerpt
Endothelial progenitor cells (EPCs) are important to tissue repair and regeneration especially after ischemic injury, and very heterogeneous in phenotypes and biological features. Reactive oxygen species are involved in regulating EPC number and function. N-acetylcysteine (NAC) inhibits ischemia-induced reactive oxygen species formation and promotes ischemic limb recovery. This study was to evaluate the effect of...
Topics
- Acetylcysteine
- Angiogenesis Inducing Agents
- Animals
- Antioxidants
- Apoptosis
- Bone Marrow Cells
- Cell Proliferation
- Disease Models, Animal
- Endothelial Progenitor Cells
- Hindlimb