Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development

6 Nov 2019

Abstract excerpt

Abdominal aortic aneurysm (AAA) is a prevalent life-threatening disease, where aortic wall degradation is mediated by accumulated immune cells. Although cytokines regulate inflammation within the aorta, their contribution to AAA via distant alterations, particularly in the control of hematopoietic stem cell (HSC) differentiation, remains poorly defined. Here we report a pathogenic role for the interleukin-27...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic aneurysm repair treatments
Share to IL-33, ST2, and ILC Pathways
Share to Immune cells in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31695038
DOI: 10.1038/s41467-019-13017-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm developmentPMID 31695038Read ↗

IL-27 receptor signaling regulated stress myelopoiesis drives Abdominal Aortic Aneurysm developmentSemantic proximity Read ↗

IL27 exerts a powerful effect on systolic overload-induced cardiac inflammation, fibrosis, and heart failure developmentSemantic proximity Read ↗

Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissectionSemantic proximity Read ↗

Single-Cell RNA Sequencing Deconstructs the Distribution of Immune Cells Within Abdominal Aortic Aneurysms in MiceSemantic proximity Read ↗

Understanding interleukin 11 as a disease gene and therapeutic targetSemantic proximity Read ↗

Protectin D1/GPR37 signaling enhances macrophage-dependent efferocytosis to attenuate experimental abdominal aortic aneurysm formationSemantic proximity Read ↗

Eosinophils Protect Mice From Angiotensin-II Perfusion-Induced Abdominal Aortic Aneurysm.Semantic proximity Read ↗

Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndromeSemantic proximity Read ↗

Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy.Semantic proximity Read ↗

GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency.Semantic proximity Read ↗

Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic AneurysmsSemantic proximity Read ↗

Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.