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Article

Aging-related decrease of human ASC angiogenic potential is reversed by hypoxia preconditioning through ROS production.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2013

De Barros Sandra, Dehez Stéphanie, Arnaud Emmanuelle, Barreau Corinne, Cazavet Alexandre, Perez Guillaume, Galinier Anne, Casteilla Louis, Planat-Bénard Valérie

Abstract excerpt

Adipose stroma/stem cells (ASC) represent an ideal source of autologous cells for cell-based therapy. Their transplantation enhances neovascularization after experimental ischemic injury. Aging is associated with a progressive decrease in the regenerative potential of mesenchymal stem cells (MSCs) from bone marrow. This work aims to determine the aging effect on human ASC capacities. First, we show that aging...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23070114
DOI: 10.1038/mt.2012.213
PMCID: PMC3594015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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