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Article

Ager Deletion Enhances Ischemic Muscle Inflammation, Angiogenesis, and Blood Flow Recovery in Diabetic Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2017

López-Díez Raquel, Shen Xiaoping, Daffu Gurdip, Khursheed Md, Hu Jiyuan, Song Fei, Rosario Rosa, Xu Yunlu, Li Qing, Xi Xiangmei, Zou Yu Shan, Li Huilin, Schmidt Ann Marie, Yan Shi Fang

Abstract excerpt

OBJECTIVE: Diabetic subjects are at higher risk of ischemic peripheral vascular disease. We tested the hypothesis that advanced glycation end products (AGEs) and their receptor (RAGE) block angiogenesis and blood flow recovery after hindlimb ischemia induced by femoral artery ligation through modulation of immune/inflammatory mechanisms. APPROACH AND RESULTS: Wild-type mice rendered diabetic with streptozotocin...

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Identifiers

PMID: 28642238
DOI: 10.1161/ATVBAHA.117.309714
PMCID: PMC5559084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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