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Article

Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration.

Diabetes - 1 Apr 2011

Kahn Matthew B, Yuldasheva Nadira Y, Cubbon Richard M, Smith Jessica, Rashid Sheikh T, Viswambharan Hema, Imrie Helen, Abbas Afroze, Rajwani Adil, Aziz Amir, Baliga Vivek, Sukumar Piruthivi, Gage Matthew, Kearney Mark T, Wheatcroft Stephen B

Abstract excerpt

OBJECTIVE: Circulating angiogenic progenitor cells (APCs) participate in endothelial repair after arterial injury. Type 2 diabetes is associated with fewer circulating APCs, APC dysfunction, and impaired endothelial repair. We set out to determine whether insulin resistance adversely affects APCs and endothelial regeneration. RESEARCH DESIGN AND METHODS: We quantified APCs and assessed APC mobilization and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin Resistance

Share to Leukocytes, Mononuclear

Share to Neovascularization, Physiologic

Share to Nitric Oxide Synthase Type III

Share to Receptor, Insulin

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Source

Open in PubMed Open full text

Identifiers

PMID: 21317296
DOI: 10.2337/db10-1080
PMCID: PMC3064103

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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