Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High affinity associations with α-SNAP enable calcium entry via Orai1 channels.

PloS one - 1 Jan 2021

Ramanagoudr-Bhojappa Ramanagouda, Miao Yong, Vig Monika

Abstract excerpt

Molecular steps that activate store-operated calcium entry (SOCE) via Orai channel supramolecular complex remain incompletely defined. We have earlier shown that α-SNAP regulates the on-site functional assembly and calcium selectivity of Orai1 channels. Here we investigate the molecular basis of its association with Orai, Stim and find that the affinity of α-SNAP for Orai and Stim is substantially higher than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Cloning, Molecular
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockout Techniques

Share to HEK293 Cells

Share to Neoplasm Proteins

Share to ORAI1 Protein

Share to Stromal Interaction Molecule 1

Source

Open in PubMed Open full text

Identifiers

PMID: 34653219
DOI: 10.1371/journal.pone.0258670
PMCID: PMC8519427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High affinity associations with α-SNAP enable calcium entry via Orai1 channels.PMID 34653219Read ↗

Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.Semantic proximity Read ↗

SOAR and the polybasic STIM1 domains gate and regulate Orai channels.Semantic proximity Read ↗

Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Semantic proximity Read ↗

Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation.Semantic proximity Read ↗

Conserved and species-specific STIM autoinhibition revealed by AlphaFold3-guided dissectionSemantic proximity Read ↗

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.Semantic proximity Read ↗

Molecular anatomy of the early events in STIM1 activation - oligomerization or conformational change?Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.Semantic proximity Read ↗

Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel.Semantic proximity Read ↗

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels.Semantic proximity Read ↗

Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.