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Article

Molecular anatomy of the early events in STIM1 activation - oligomerization or conformational change?

Journal of cell science - 1 Sept 2017

Korzeniowski Marek K, Wisniewski Eva, Baird Barbara, Holowka David A, Balla Tamas

Abstract excerpt

Decreased luminal endoplasmic reticulum (ER) Ca2+ concentration triggers oligomerization and clustering of the ER Ca2+ sensor STIM1 to promote its association with plasma membrane Orai1 Ca2+ channels leading to increased Ca2+ influx. A key step in STIM1 activation is the release of its SOAR domain from an intramolecular clamp formed with the STIM1 first coiled-coil (CC1) region. Using a truncated STIM1(1-343)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28724757
DOI: 10.1242/jcs.205583
PMCID: PMC5612226

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Molecular anatomy of the early events in STIM1 activation - oligomerization or conformational change?PMID 28724757Read ↗

Intramolecular shielding maintains the ER Ca²⁺ sensor STIM1 in an inactive conformation.Semantic proximity Read ↗

Activation of STIM1-Orai1 involves an intramolecular switching mechanism.Semantic proximity Read ↗

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels.Semantic proximity Read ↗

Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.Semantic proximity Read ↗

Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.Semantic proximity Read ↗

Sequential Steps of CRAC Channel Activation.Semantic proximity Read ↗

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.Semantic proximity Read ↗

SOAR and the polybasic STIM1 domains gate and regulate Orai channels.Semantic proximity Read ↗

Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1.Semantic proximity Read ↗

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding.Semantic proximity Read ↗

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