Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.

The Journal of biological chemistry - 7 Aug 2009

Frischauf Irene, Muik Martin, Derler Isabella, Bergsmann Judith, Fahrner Marc, Schindl Rainer, Groschner Klaus, Romanin Christoph

Abstract excerpt

STIM1 and Orai1 have been reported to interact upon store depletion culminating in Ca(2+) release-activated Ca(2+) current activation. Recently, the essential region has been identified within the STIM1 C terminus that includes the second coiled-coil domain C-terminally extended by approximately 50 amino acids and exhibits a strong binding to the Orai1 C terminus. Based on the homology within the Orai family, an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channels
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Neoplasm Proteins

Share to ORAI1 Protein

Share to Protein Structure, Secondary

Share to Recombinant Fusion Proteins

Share to Stromal Interaction Molecule 1

Source

Open in PubMed Open full text

Identifiers

PMID: 19506081
DOI: 10.1074/jbc.M109.018408
PMCID: PMC2755892

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.PMID 19506081Read ↗

Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.Semantic proximity Read ↗

Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding.Semantic proximity Read ↗

Molecular anatomy of the early events in STIM1 activation - oligomerization or conformational change?Semantic proximity Read ↗

SOAR and the polybasic STIM1 domains gate and regulate Orai channels.Semantic proximity Read ↗

High affinity associations with α-SNAP enable calcium entry via Orai1 channels.Semantic proximity Read ↗

STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction.Semantic proximity Read ↗

Activation of STIM1-Orai1 involves an intramolecular switching mechanism.Semantic proximity Read ↗

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.Semantic proximity Read ↗

Conserved and species-specific STIM autoinhibition revealed by AlphaFold3-guided dissectionSemantic proximity Read ↗

Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.