Article
Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits.
The Journal of general physiology - 1 Oct 2018
Yen Michelle, Lewis Richard S
Abstract excerpt
The binding of STIM1 to Orai1 controls the opening of store-operated CRAC channels as well as their extremely high Ca2+ selectivity. Although STIM1 dimers are known to bind directly to the cytosolic C termini of the six Orai1 subunits (SUs) that form the channel hexamer, the dependence of channel activation and selectivity on the number of occupied binding sites is not well understood. Here we address these...
Topics
- Calcium Release Activated Calcium Channels
- HEK293 Cells
- Humans
- Mutation
- Stromal Interaction Molecule 1