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Article

Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 17 Mar 2020

Bhardwaj Rajesh, Augustynek Bartłomiej S, Ercan-Herbst Ebru, Kandasamy Palanivel, Seedorf Matthias, Peinelt Christine, Hediger Matthias A

Abstract excerpt

BACKGROUND/AIMS: Store-operated Ca2+ entry (SOCE) through plasma membrane Ca2+ channel Orai1 is essential for many cellular processes. SOCE, activated by ER Ca2+ store-depletion, relies on the gating function of STIM1 Orai1-activating region SOAR of the ER-anchored Ca2+-sensing protein STIM1. Electrophysiologically, SOCE is characterized as Ca2+ release-activated Ca2+ current (ICRAC). A major regulatory mechanism...

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Identifiers

PMID: 32176842
DOI: 10.33594/000000218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel.PMID 32176842Read ↗

A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.Semantic proximity Read ↗

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

SOAR and the polybasic STIM1 domains gate and regulate Orai channels.Semantic proximity Read ↗

Gated regulation of CRAC channel ion selectivity by STIM1.Semantic proximity Read ↗

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.Semantic proximity Read ↗

Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Semantic proximity Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels.Semantic proximity Read ↗

Intramolecular shielding maintains the ER Ca²⁺ sensor STIM1 in an inactive conformation.Semantic proximity Read ↗

Activation of STIM1-Orai1 involves an intramolecular switching mechanism.Semantic proximity Read ↗

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.Semantic proximity Read ↗

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