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Article

Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation.

Cell reports - 29 Jun 2021

Baraniak James H, Zhou Yandong, Nwokonko Robert M, Jennette Michelle R, Kazzaz Sarah A, Stenson Jazmin M, Whitsell Abigale L, Wang Youjun, Trebak Mohamed, Gill Donald L

Abstract excerpt

Junctional coupling between endoplasmic reticulum (ER) Ca2+-sensor STIM proteins and plasma membrane (PM) Orai channels mediates Ca2+ signals in most cells. We reveal that PM-tethered, fluorescently tagged C-terminal M4x (fourth transmembrane helix contains a cytoplasmic C-terminal extension) peptides from Orai channels undergo a Leu-specific signature of direct interaction with the STIM1 Orai-activating region...

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Boron Compounds
Calcium Channels
Calcium Signaling
Cytosol
Leucine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NFATC Transcription Factors

Stromal Interaction Molecule 1

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PMID: 34192542
DOI: 10.1016/j.celrep.2021.109322
PMCID: PMC8462482

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