Article
STIM1 dimers undergo unimolecular coupling to activate Orai1 channels.
Nature communications - 24 Sept 2015
Zhou Yandong, Wang Xizhuo, Wang Xianming, Loktionova Natalia A, Cai Xiangyu, Nwokonko Robert M, Vrana Erin, Wang Youjun, Rothberg Brad S, Gill Donald L
Abstract excerpt
The endoplasmic reticulum (ER) Ca(2+) sensor, STIM1, becomes activated when ER-stored Ca(2+) is depleted and translocates into ER-plasma membrane junctions where it tethers and activates Orai1 Ca(2+) entry channels. The dimeric STIM1 protein contains a small STIM-Orai-activating region (SOAR)--the minimal sequence sufficient to activate Orai1 channels. Since SOAR itself is a dimer, we constructed SOAR...
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