Article
Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.
The Journal of biological chemistry - 19 Apr 2013
Zheng Hongying, Zhou Meng-Hua, Hu Changlong, Kuo Enoch, Peng Xu, Hu Junjie, Kuo Lih, Zhang Shenyuan L
Abstract excerpt
The entry of extracellular Ca(2+), which is mediated by Ca(2+) release-activated Ca(2+) (CRAC) channels, is essential for T cell activation and the normal functioning of other immune cells. Although the molecular components of CRAC channels, the Orai1 pore-forming subunit and the STIM1-activating subunit have been recently identified, the gating mechanism by which Orai1 channels conduct Ca(2+) entry upon...
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