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Article

Molecular and Computational Bases for Spirofuranone Formation in Setosusin Biosynthesis.

Journal of the American Chemical Society - 27 Oct 2021

Wei Xingxing, Matsuyama Taro, Sato Hajime, Yan Dexiu, Chan Pui Man, Miyamoto Kazunori, Uchiyama Masanobu, Matsuda Yudai

Abstract excerpt

The 3(2H)-furanone unit is observed in many biologically active natural products, as represented by the antifungal medication griseofulvin. Setosusin (1) is a fungal meroditerpenoid featuring a unique spiro-fused 3(2H)-furanone moiety; however, the biosynthetic basis for spirofuranone formation has not been investigated since its isolation. Therefore, in this study we identified the biosynthetic gene cluster of 1...

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PMID: 34644070
DOI: 10.1021/jacs.1c08336

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