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Article

Redesign of a central enzyme in alkaloid biosynthesis.

Chemistry & biology - 1 Nov 2006

Chen Shi, Galan M Carmen, Coltharp Carla, O'Connor Sarah E

Abstract excerpt

Plant alkaloids exhibit a diverse array of structures and pharmaceutical activities, though metabolic engineering efforts in these eukaryotic pathways have been limited. Strictosidine synthase (STR) is the first committed step in the biosynthesis of over two thousand terpene indole alkaloids. We describe a rational redesign of the STR binding pocket to selectively accommodate secologanin substrate analogs. The...

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Identifiers

PMID: 17113995
DOI: 10.1016/j.chembiol.2006.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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