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Article

Enantioselective Synthesis of Bicyclic Lactone Enabled by Tunnel Reshaping of Polycyclic Ketone Monooxygenase.

Journal of agricultural and food chemistry - 17 Jun 2026

Chen Jingjing, Xu Xinqi, Lin Juan

Abstract excerpt

The Baeyer-Villiger monooxygenase (BVMO)-mediated oxidation of racemic cyclobutanone offers an attractive route to (1S,5R)-bicyclic lactone for the synthesis of unsaturated fatty acid prostaglandin. However, limited enantioselectivity restricts the applicability of this method. In this work, a thermostable BVMO PockeMO was engineered in the active site and substrate tunnel to obtain the quadruple mutant MU4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42233521
DOI: 10.1021/acs.jafc.6c01110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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