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Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

30 Oct 2018

Abstract excerpt

Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However, biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible gene cluster for fusidic acid ( fus cluster). This gene cluster consists of eight genes, among which six are...

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PMID: 30972287
DOI: 10.1016/j.apsb.2018.10.007

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