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Article

Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions.

The Journal of biological chemistry - 2 Nov 2012

Li Shengying, Tietz Drew R, Rutaganira Florentine U, Kells Petrea M, Anzai Yojiro, Kato Fumio, Pochapsky Thomas C, Sherman David H, Podust Larissa M

Abstract excerpt

The majority of characterized cytochrome P450 enzymes in actinomycete secondary metabolic pathways are strictly substrate-, regio-, and stereo-specific. Examples of multifunctional biosynthetic cytochromes P450 with broader substrate and regio-specificity are growing in number and are of particular interest for biosynthetic and chemoenzymatic applications. MycG is among the first P450 monooxygenases characterized...

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Identifiers

PMID: 22952225
DOI: 10.1074/jbc.M112.410340
PMCID: PMC3488060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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