Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FK506 Maturation Involves a Cytochrome P450 Protein-Catalyzed Four-Electron C-9 Oxidation in Parallel with a C-31<i>O</i>-Methylation

23 Feb 2013

Abstract excerpt

FK506, structurally similar to FK520 and rapamycin, is an α-keto amide bonding-containing, macrolide natural product that exhibits potent immunosuppressive activity and moderate antifungal activity. FK506 biosynthesis requires a hybrid polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) system to construct the skeleton of the macrolide. The mechanism for tailoring this macrolide to furnish FK506...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microbial Natural Products and Biosynthesis
Share to Peptidase Inhibition and Analysis
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23435975
DOI: 10.1128/jb.00033-13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FK506 Maturation Involves a Cytochrome P450 Protein-Catalyzed Four-Electron C-9 Oxidation in Parallel with a C-31<i>O</i>-MethylationPMID 23435975Read ↗

Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520Semantic proximity Read ↗

Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit.Semantic proximity Read ↗

StreptomycesCytochrome P450 Enzymes and Their Roles in the Biosynthesis of Macrolide Therapeutic AgentsSemantic proximity Read ↗

Novel chemobiosynthetic approach for exclusive production of FK506Semantic proximity Read ↗

Designed Biosynthesis of 36-Methyl-FK506 by Polyketide Precursor Pathway EngineeringSemantic proximity Read ↗

Structural Organization of A Multifunctional Polyketide Synthase Involved in the Biosynthesis of the Macrolide Immunosuppressant FK506Semantic proximity Read ↗

Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP.Semantic proximity Read ↗

Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by <i>in situ</i> esterase-mediated deprotectionSemantic proximity Read ↗

Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade.Semantic proximity Read ↗

Biochemistry-Guided Prediction of the Absolute Configuration of Fungal Reduced Polyketides.Semantic proximity Read ↗

Improvement of FK506 Production in Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination SystemsSemantic proximity Read ↗

Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.