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Article

Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry.

Journal of the American Chemical Society - 18 Jul 2012

Zu Liansuo, Xu Meimei, Lodewyk Michael W, Cane David E, Peters Reuben J, Tantillo Dean J

Abstract excerpt

Mechanistic proposals for the carbocation cascade reaction leading to the tricyclic sesquiterpene pentalenene are assessed in light of the results of isotopically sensitive branching experiments with the H309A mutant of pentalenene synthase. These experimental results support a mechanism for pentalenene formation involving a 7-protoilludyl cation whose intermediacy was first predicted using quantum-chemical...

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PMID: 22738258
DOI: 10.1021/ja3043245
PMCID: PMC3402234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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