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Article

Whole-exome sequencing of rectal cancer identifies locally recurrent mutations in the Wnt pathway.

Aging - 12 Oct 2021

Yang Yi, Gu Xiaodong, Li Zhenyang, Zheng Chuang, Wang Zihao, Zhou Minwei, Chen Zongyou, Li Mengzhen, Li Dongbing, Xiang Jianbin

Abstract excerpt

Locally recurrent rectal cancer (LRRC) leads to a poor prognosis and appears as a clinically predominant pattern of failure. In this research, whole-exome sequencing (WES) was performed on 21 samples from 8 patients to search for the molecular mechanisms of LRRC. The data was analyzed by bioinformatics. Gene Expression Profiling Interactive Analysis (GEPIA) and Human Protein Atlas (HPA) were performed to validate...

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Identifiers

PMID: 34642262
DOI: 10.18632/aging.203618
PMCID: PMC8544332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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