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Article

Genetic variations using whole-exome sequencing might predict response for neoadjuvant chemoradiotherapy in locally advanced rectal cancer.

Medical oncology (Northwood, London, England) - 11 Sept 2018

Lee In Hee, Kang Keunsoo, Kang Byung Woog, Lee Soo Jung, Bae Woo Kyun, Hwang Jun Eul, Kim Hye Jin, Park Su Yeon, Park Jun Seok, Choi Gyu Seog, Kim Jong Gwang

Abstract excerpt

A good pathologic response to neoadjuvant chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC) is associated with a better prognosis. However, there is no effective method to predict CRT response in LARC patients. Therefore, this study used whole-exome sequencing (WES) to identify novel biomarker predicting CRT benefit in LARC. Two independent tumor tissue sets were used to evaluate the genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30206710
DOI: 10.1007/s12032-018-1202-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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