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Article

Genetic Determinants of Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer Identified by Whole Exome Sequencing.

Annals of human genetics - 1 Mar 2026

Peric Jelena, Dragicevic Sandra, Miladinov Marko, Rom Aleksandra Djikic, Bjelanovic Jasna, Kovac Jelena, Despotovic Jovana, Babic Tamara, Ljubicic Jelena, Pavlovic Dunja, Stojkovic Jovana Rosic, Dimitrijevic Ivan, Barisic Goran, Markovic Velimir, Nikolic Aleksandra

Abstract excerpt

BACKGROUND: Neoadjuvant chemoradiotherapy (nCRT) is essential for treating locally advanced rectal cancer (LARC), however response to nCRT varies, and reliable predictors are lacking. METHODS: This study used whole exome sequencing analysis to investigate genetic differences between tumors highly responsive and non-responsive to nCRT. Five patients with good response and two patients without response to nCRT were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40746047
DOI: 10.1111/ahg.70019

Genes

SLC16A6
SLC25A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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