Article
Genome landscapes of rectal cancer before and after preoperative chemoradiotherapy.
Theranostics - 1 Jan 2019
Yang Jie, Lin Yuan, Huang Ying, Jin Jing, Zou Shuangmei, Zhang Xiaolong, Li Hongmin, Feng Ting, Chen Jinna, Zuo Zhixiang, Zheng Jian, Li Yexiong, Gao Ge, Wu Chen, Tan Wen, Lin Dongxin
Abstract excerpt
Resistance to preoperative chemoradiotherapy (CRT) is a major obstacle to cancer treatment in patients with locally advanced rectal cancer. This study was to explore genome alterations in rectal cancer under CRT stress. Methods: Whole-exome sequencing (WES) was performed on 28 paired tumors collected before and after CRT from the same patients who did not respond to CRT treatment. Somatic point mutations and copy...
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