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Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer

9 Aug 2019

Abstract excerpt

Epigenetic alterations play a central role in cancer development and progression. The acetylation of histone 3 at lysine 27 (H3K27ac) specifically marks active genes. While chromatin immunoprecipitation (ChIP) followed by next-generation sequencing (ChIP-seq) analyses are commonly performed in cell lines, only limited data are available from primary tumors. We therefore examined whether cancer-specific...

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PMID: 31404997
DOI: 10.3390/cancers11081142

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