Article
Molecular typing and mutational characterization of rectal neuroendocrine neoplasms.
Cancer medicine - 1 Aug 2023
Duan Xiaoling, Zhao Man, Yin Xiaolei, Mi Lili, Shi Jianfei, Li Ning, Han Xin, Han Guangjie, Wang Jinfeng, Hou Jiaojiao, Yin Fei
Abstract excerpt
BACKGROUND: Rectal neuroendocrine neoplasms (NENs) are rare neoplasms with limited understanding of its genomic alterations and molecular typing. METHODS: The paraffin-embedded tissue specimens of 38 patients with rectal NENs after surgery were subjected to whole gene sequencing (WGS), and mutation profilings were drawn to identify high-frequency mutation genes, copy-number variations (CNVs), tumor mutation...
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