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Article

CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.

Molecular biology of the cell - 1 Dec 2021

Sarkar Moumita, Martufi Matteo, Roman-Trufero Monica, Wang Yi-Fang, Whilding Chad, Dormann Dirk, Sabbattini Pierangela, Dillon Niall

Abstract excerpt

Mesendoderm cells are key intermediate progenitors that form at the early primitive streak (PrS) and give rise to mesoderm and endoderm in the gastrulating embryo. We have identified an interaction between CNOT3 and the cell cycle kinase Aurora B that requires sequences in the NOT box domain of CNOT3 and regulates MAPK/ERK signaling during mesendoderm differentiation. Aurora B phosphorylates CNOT3 at two sites...

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Source

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Identifiers

PMID: 34613789
DOI: 10.1091/mbc.E21-02-0089
PMCID: PMC8694085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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