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Article

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development

26 May 2011

Abstract excerpt

Mitosis is controlled by multiple kinases that drive cell cycle progression and prevent chromosome mis-segregation. Aurora kinase B interacts with survivin, borealin and incenp to form the chromosomal passenger complex (CPC), which is involved in the regulation of microtubule-kinetochore attachments and cytokinesis. Whereas genetic ablation of survivin, borealin or incenp results in early lethality at the morula...

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PMID: 21613325
DOI: 10.1242/dev.066381

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Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian developmentPMID 21613325Read ↗

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