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Article

Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crest.

Mechanisms of development - 1 Jan 2000

Morgan Sarah C, Lee Hyung-Yul, Relaix Frédéric, Sandell Lisa L, Levorse John M, Loeken Mary R

Abstract excerpt

During neural tube closure, Pax3 is required to inhibit p53-dependent apoptosis. Pax3 is also required for migration of cardiac neural crest (CNC) from the neural tube to the heart and septation of the primitive single cardiac outflow tract into the aorta and pulmonary arteries. Whether Pax3 is required for CNC migration and outflow tract septation by inhibiting p53-dependent apoptosis is not known. In this...

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Identifiers

PMID: 18672055
DOI: 10.1016/j.mod.2008.07.003
PMCID: PMC2654333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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