Article

DIS3L2 is essential for neural crest survival by modulating Akt signaling

2024-12-27

Abstract excerpt

DIS3 like 3’-5’ exoribonuclease 2 (DIS3L2), an exoribonuclease is known to preferentially degrade uridylated RNA substrates, miRNAs, and ncRNAs. Recent reports show that DIS3L2 also plays a key role in cell proliferation and tumor growth. Mutations in DIS3L2 are associated with congenital disorders such as Perlman syndrome, yet the developmental functions of DIS3L2 remain unknown. We report the developmental role...

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Literature Corpus work: a8a67202-44ba-5c18-9c1a-fce7167faa8f
DOI: 10.1101/2024.12.26.630456

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